Table 4:
Comparison of expression of GLP-1R-mApple+ cells compared to the previously published mouse transgenic model [(Cork et al., 2015)] and RNA transcript in rat [(Merchenthaler et al., 1999)]. Table modified from (Cork et al., 2015). ND = not determined.
| GLP-1R-mApple model | Cork, et al. (2015) transgenic mouse | Merchenthaler, et al. (1999) rat in situ | |
|---|---|---|---|
| Telencephalon | |||
| Olfactory | |||
| Granule cell layer | ++ | ++ | ND |
| Anterior olfactory area | |||
| Dorsal | + | ++ | ND |
| Lateral | + | +++ | ND |
| Ventral | + | +++ | ND |
| Nucleus accumbens | +a | ||
| Shell | + | + | |
| Core | + | + | |
| Islands of Calleja | +++ | ND | ND |
| Ventral tenia tecta | ++ | ++ | ND |
| Claustrum | +++ | ++ | ND |
| Lateral Septum | |||
| Intermediate | ++ | ++ | ++ |
| Dorsal | ++++ | ++++ | ND |
| Ventral | ++++ | +++ | ND |
| Medial Septum | + | ND | ND |
| Subfornical organ | ++++ | ++++ | ND |
| Triangular septal nucleus | ++++ | ND | ND |
| Cortex | + | + | −a |
| Cingulate | + | + | |
| Piriform | ++ | ++ | |
| Bed nucleus of the stria terminalis | +++ | +++ | + |
| Septohypothalamic nuclei | ++ | ++ | ND |
| Preoptic area | |||
| Medial | + | + | ND |
| Lateral | ++ | + | ND |
| Ventral | ++ | ++ | ND |
| Median | +++ | ++ | ND |
| Hippocampus | |||
| CA3 | |||
| Rostral (Dorsal) | − | + | − |
| Caudal (Ventral) | +++ | +++ | + |
| CA1 (Caudal/Ventral) | + | ++ | ND |
| Dentate gyrus | +++ | ++ | ND |
| Central Amygdala | +++ | ++++ | − |
| Medial Amygdala | ++ | +++ | − |
| Basolateral Amygdala | − | ++ | ND |
| Cortical Amygdala | + | ++ | ND |
| Organum vasculosum laminae terminalis | ++ | + | ND |
| Diencephalon | |||
| Thalamus | |||
| Anterior thalamic nuclei | − | +++ | − |
| Ventral posteriomedial thalamic nuclei | − | +++ | ND |
| Paraventricular nucleus | + | + | ND |
| Geniculate nucleus | |||
| Dorsolateral | + | ++ | ND |
| Pregeniculate | + | ++ | ND |
| Medial | ++ | ++ | ND |
| Zona incerta | ++ | +++ | ++ |
| Nucleus reuniens | + | ++ | + |
| Parasubthalamic nucleus | + | + | ND |
| Ventral anterior thalamic nucleus | + | +++ | ND |
| Posterior thalamus | ++ | +++ | ND |
| Parafascicular thalamic nucleus | ++ | ++ | +++ |
| Precommissural nucleus | +++ | +++ | ND |
| Mediodorsal nucleus | +++ | ++++ | ND |
| Ventromedial thalamic nucleus | + | ++ | ND |
| Lateral habenular nucleus | − (++ fibers) | ++ | ND |
| Medial habenular nucleus | − (++++ fibers) | ND | ND |
| Thalamic reticular formation | + | ++ | ND |
| Hypothalamus | |||
| Anterior hypothalamus | + | ++ | ND |
| Dorsomedial hypothalamus | +++ | ++ | + |
| Paraventricular nucleus | +++ | +++ | ++++ |
| Arcuate nucleus | +++ | +++ | ++++ |
| Lateral Hypothalamus | ++ | ++ | + |
| Posterior hypothalamus | + | ++ | ND |
| Suprachiasmatic nucleus | ++ | +++ | ND |
| Retrochiasmatic nucleus | +++ | +++ | ND |
| Accessory neurosecretory nuclei | ++ | ++ | ND |
| Ventromedial hypothalamus | +++ | +++ | + |
| Mesencephalon | |||
| Periaqueductal grey | ++ | +++ | +++ |
| Premamilliary nucleus | ++ | + | ND |
| Mammilliary nucleus | +++ | ++ | ND |
| Posterior commissure | +++ | +++ | ND |
| Pretectal nucleus | |||
| Anterior | ++ | ++ | ND |
| Medial | ++ | +++ | ND |
| Posterior | ++ | +++ | ND |
| Olivary | ++ | +++ | ND |
| Superior colliculus | ++ | +++ | ++ |
| Ventral tegmental area | + | + | ++ |
| Substantia nigra | ++ | ND | ND |
| Parasubthalamic nucleus | ++ | ++ | ND |
| Brainstem | |||
| Area postrema | ++++ | ++++ | ++++ |
| Nucleus tractus solitarius | + | + | +++ |
| Nucleus of Roller | + | + | ND |
| Reticular formation | ++ | ++ | ND |
| Rostral ventrolateral medulla | ++ | ++ | ND |
| Locus coeruleus | ++ | ++ | ND |
a
transcript data in rat is further divided into subregions.