Table 3.
Bleeding rates in week 1 to 12
| Variable | No. of events | Observation time (patient-weeks) | Mean rate per patient-week (95% CI) |
|---|---|---|---|
| Total bleeds | 130 | 1069 | 0.13 (0.10-0.17) |
| Total bleeds before achieving PR | 116 | 441 | 0.27 (0.21-0.34) |
| Nonrecurrent bleeds | 97 | 1069 | 0.09 (0.07-0.12) |
| Recurrent bleeds | 30 | 1069 | 0.03 (0.02-0.05) |
| Treated bleeds | 91 | 1069 | 0.09 (0.07-0.13) |
| Untreated bleeds | 36 | 1069 | 0.03 (0.02-0.05) |
Means and confidence intervals (CIs) were estimated by using a negative binomial distribution function.