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. 2020 Jul 30;11(7):569. doi: 10.1038/s41419-020-02775-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — In comparison to WT mice, R6/1 mice display increased RTP801 at the striatal synapse along with increased Rictor and P-Akt (Ser473) and motor-learning deficits. RTP801 silencing preserves corticostriatal motor-learning function by decreasing the levels of Rictor and P-Akt Ser473 and enhancing postsynaptic signaling by increasing GluA1 and TrkB receptors.