Fig. 4.

Profile of fecal bile acids from HFD mice after 8 weeks of oral treatment with IX.

Effect of the oral administration of IX for 8 weeks on the profile of bile acids in HFD-fed mice. Fecal contents of each bile acid are presented as means ± SE of 4–8 mice whose feces were successfully collected. When data were under the limit of quantification (LOQ), they were replaced by the concentration at the LOQ. *p<0.05 between the ND and HFD groups (Student’s t-test). #p<0.05 between the HFD and other groups (Dunnett’s test). n.d.: not detected (under LOQ) in any mice; IX: isoxanthohumol; ND: normal diet; HFD: high-fat diet; CA: cholic acid; DCA: deoxycholic acid; α-MCA: α-muricholic acid; β-MCA: β-muricholic acid; ω-MCA: ω-muricholic acid; HDCA: hyodeoxycholic acid; TCA: taurocholic acid; T-β-MCA: tauro-β-muricholic acid.