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. 2020 Jul 24;11:1141. doi: 10.3389/fphar.2020.01141

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Copyright © 2020 Sharma, Dando, Strippoli, Kumar, Somoza, Cordani and Tafani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nanoparticles for delivery of miRNA-34a for autophagy inhibition. Schematic representation showing the effects of nanoparticles functionalized with anti-autophagy miRNA-34a in cancer cells. Upon intracellular stimulus, NPs can release therapeutic miRNA-34a and restore its cellular physiological levels. miRNA-34a can exert its tumor suppressor activity by downregulating autophagy-related genes and inhibiting protective autophagy. Blocking cancer autophagy leads to cancer cell death either directly or by sensitizing them to chemotherapy treatment.