Table 1.
Nanoparticles for delivery of autophagy-related miRNA-34a as cancer treatment.
| Entry | Nanoparticles | Compound carried/co-treatment | Tested cell lines (tissue of origin) | In vivo models | Biological effects | Molecular mechanisms | Refs |
|---|---|---|---|---|---|---|---|
| 1 | SiO2-NPs | None | SUM159pt; mammospheres (breast cancer) |
mutant miR34-TKO mice; NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mice | Reduction of mammosphere formation; Reduction in tumor growth in vivo. |
Notch-1↓ | (Panebianco et al., 2019) |
| 2 | CaPs | Linear polyethyleneimine (LPEI) | PC3 (prostate cancer) | None | Inhibition of cell proliferation; Inhibition of cell migration |
Not reported | (Jung et al., 2015) |
| 3 | AuNPs | 7-ethyl-10-hidroxycamptothecin (SN-38) microRNA-182, microRNA-137 and microRNA-144 |
Mel-202 (uveal melanoma) | none | Synergistic increase in cytotoxicity; Sensitization to SN-38 |
c-MET↓ | (Milán Rois et al., 2018) |
| 4 | AuNSsh | None | MDA-MB-231 (breast cancer) | None | Inhibition of cell proliferation; Inhibition of metabolic activity |
SIRT1↓; Bcl2↓ | (Li et al., 2013) |
| 5 | MNPs | Nitrosonium tetrafluoroborate (NOBF4); Polyethylene glycol (PEG) | Not reported | None | Inhibition of cell migration and invasion | CD44↓ | (Lee et al., 2016) |
| 6 | CPP-9 (CRGDKGPDC) | b-cyclodextrin-polyethylenimine (PC) |
PANC-1 (pancreatic cancer) |
Athymic female mice (BALB/c strain) | Cell cycle arrest; apoptosis; suppression tumor cell migration; reduction tumor growth in vivo. | E2F3↓; Bcl-2↓; c-myc↓; cyclin D1↓ |
(Hu et al., 2013) |
| 7 | CPP Nona arginine (R9) | c(RGDfK) and Folic acid (targeting ligands) |
U87MG and HeLa (Breast and ovarian cancer) | None | Not reported | Not reported | (Xiao et al., 2018) |
| 8 | SLNs | Dimethyldioctadecylammonium bromide (DDAB) |
B16F10-CD44+ (Lung metastasis of melanoma) | Female C57BL/6 mice | Induction of apoptosis; Reduction of cell migration; Reduction of spheroids formation in vitro; Inhibition of tumor growth and metastasis in vivo |
CD44↓ | (Shi et al., 2013) |
| 9 | SLNs | Paclitaxel (PTX) | B16F10-CD44+ (Lung metastasis of melanoma) | Female C57BL/6 mice | Synergistic inhibition of cancer development and metastasis | CD44↓ | (Shi et al., 2014) |
| 10 | LPH | Polyethylene glycol (PEG), Single-chain antibody fragment (scFv) |
B16F10-CD44+ (Lung metastasis of melanoma) | None | Induction of apoptosis | Survivin↓ MAPK↓ |
(Chen et al., 2010) |
| 11 | PAMAMs | Phenylboronic acid (PBA) | BGC-823 (Gastric cancer) |
BALB/c-nude mice | Induction of apoptosis; Reduction of cancer cells invasion and migration; Reduction of tumor growth in vivo. |
Notch-1↓ | (Song et al., 2019) |
| 12 | PAMAMs | S6 aptamer | A549 (Lung cancer) |
None | Induction of apoptosis; Inhibition of cell growth, cell migration and invasion |
P53↓ Bcl-2↓ |
(Wang et al., 2015a) |
| 13 | DSS-BEN | 1,N11-bisethylnorspermine (BENSpm). |
HCT116 (colorectal carcinoma) |
Xenograft athymic nude mice |
Inhibition of polyamines metabolism; Cancer cell death; Inhibition of tumor growth in vivo. |
SMOX↑ SSAT↑ Bcl-2↓ |
(Xie et al., 2017) |
| 14 | CBSA | Docetaxel (DTX) | 4T1, A549 (breast and lung cancer) |
4T1 tumor-bearing mice | Induction of apoptosis; Cytotoxicity; Inhibition of cell migration; Inhibition of tumor growth in vivo. |
Bcl-2↓ | (Zhang et al., 2017) |
| 15 | HP-IPECs | None | MDAMB-231 and MCF-7 (breast cancer) |
Female athymic nude Balb/c mice | Induction of apoptosis; Inhibition of cell migration; inhibition of cell proliferation; reduction of tumor growth in vivo. |
Notch-1↓ CD44↓ |
(Wang et al., 2015b) |
| 16 | Chitosan-NPs | Poly(D,L-lactide-co-glycolide) (PLGA) | SKMM1 and RPMI8226 (multiple myeloma) |
Immunodeficient NOD–SCID mice | Reduction cell proliferation and toxicity in cell lines; Reduction of tumor growth in vivo. |
Bcl-2↓ CDK6↓ |
(Cosco et al., 2015) |
| 17 | Chitosan-NPs | Hyaluronic Acid (HA) Doxorubicin (DOX) |
MDA-MB-231 (triple negative breast cancer) |
Female athymic nude Balb/c | Induction of apoptosis; Reduction of cell proliferation; Inhibition of cancer cell migration; Inhibition of tumor growth in vivo. |
Bcl-2↓ Notch-1↓ |
(Deng et al., 2014) |
| 18 | Hyaluronic acid-poly(ethylene imine) (HA-PEI)-NPs HA-poly(ethylene glycol) (HA-PEG) |
None | A549 (cisplatin sensitive) and A549 DDP (cisplatin resistant) (lung cancer) |
None | Increased ATP levels; Reduction glycolysis; Elevation of mitochondrial complexes activity; Gene-Specific Changes in mtDNA encoded genes; Alteration of mitochondrial epigenetic enzymes; Induction of apoptosis. |
Bax↑ Apaf-1↑ PUMA↑ caspase3↑ Bcl-2↓ survivin↓ mt-TET1-3↑ Complex I ↑ Complex IV↑ |
(Trivedi et al., 2017) |
| 19 | β- cyclodextrin-PEI600-NPs |
polyethylene glycol (PEG) | B16F10 (melanoma) |
B16F10-CD44+ xenograft model of female C57BL/6 mice | Inhibition of tumor progression; Inhibition of cell invasion; Inhibition of sphere formation; Reduction of tumor growth in vivo. |
CD44↓ | (Fan et al., 2017) |
| 20 | poly(L-lysine-graft-imidazole) (PLI) | polyethylene glycol (PEG) | MKN-74 (gastric cancer) |
Orthotopic and subcutaneous xenograft model of male BALB/c-nude mice | Reduction metastasis and cell invasion; Induction of apoptosis; Inhibition of tumor relapse and growth in vivo. |
CD44↓ Bcl-2↓ Oct-3/4↓ Nanog↓ |
(Jang et al., 2016) |