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. 2020 Jul 30;11:3793. doi: 10.1038/s41467-020-17641-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Distribution of p-values obtained from unpaired two-sided t-test of intensities of frequently observed human peptides (n = 2904). Boxplots show p-values obtained when comparing samples containing the ovarian cancer tissue proportions indicated (ranging from 3.125% to 25%). Results are shown before normalisation (green) and after ProNorM (orange). The box indicates quartiles and the whiskers indicate the rest of the distribution, with outliers not shown. A black dashed line indicates a p-value of 0.05 and **** denotes P < 0.0001. b Percentage of frequently observed human peptides that were significantly different (vertical axis) in simulated cohorts of varying sizes (horizontal axis). Plots show comparison between Sample 2 (containing 3.125% ovarian cancer tissue) and Samples 2–5 (containing 3.125–25% ovarian cancer tissue), without normalisation (left) and after ProNorM (right). Shading denotes 95% confidence intervals derived from ten iterations of random selections of replicates of each sample. For statistical tests in both (a, b), the mean of each peptide was first calculated within each set of assigned technical triplicates. Source data are provided as a Source data file.