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. 2020 Jul 30;10:12881. doi: 10.1038/s41598-020-69736-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Canstatin prevents left ventricular (LV) dilatation and dysfunction after MI. Recombinant mouse canstatin (20 μg/kg) or vehicle was intraperitoneally administered for 28 days after LAD ligation in rats. Echocardiography was performed to analyze LV diameter and function. (A) Representative M-mode images from parasternal short-axis view of the LV in SHAM + vehicle, SHAM + canstatin, MI + vehicle and MI + canstatin groups were shown. Scale bar: 100 ms (horizontal) and 5 mm (vertical). LVIDd: left ventricular diameter at end-diastole (double headed red arrow). LVIDs: left ventricular diameter at end-systole (double headed blue arrow). Time course of LVIDd (B), LVIDs (C), fractional shortening (FS: C) and ejection fraction (EF: D) at 3, 7, 14, 21 and 28 days after MI was shown as mean ± standard error of the mean (S.E.M.). (SHAM + vehicle and SHAM + canstatin: n = 6; MI + vehicle: n = 8–17; MI + canstatin: n = 8–11). **P < 0.01 vs. SHAM + vehicle, ## P < 0.01 vs. MI + vehicle (two-way ANOVA followed by Tukey’s post hoc test).