Table 1.
Demographics and clinicopathologic characteristics of primary and secondary osteosarcomas.
| Primary Osteosarcoma | Secondary Osteosarcoma | p value | ||
|---|---|---|---|---|
| Total cases | 5860 (100) | 268 (100) | ||
| Age at diagnosis (years) | 29.8 ± 21.5 | 55.1 ± 24.3 | < 0.001 | |
| Sex | 0.007 | |||
| Male | 3,236 (55.2) | 125 (46.6) | ||
| Female | 2624 (44.8) | 143 (53.4) | ||
| Race | 0.716 | |||
| White | 4447 (75.9) | 206 (76.9) | ||
| Others | 1413 (24.1) | 62 (23.1) | ||
| Marital status at diagnosis | < 0.001 | |||
| Married | 1504 (25.7) | 180 (67.2) | ||
| Un-married | 4356 (74.3) | 88 (32.8) | ||
| Year of diagnosis | 0.197 | |||
| 1973–1994 | 1501 (25.6) | 59(22.0) | ||
| 1995–2015 | 4359 (74.4) | 209(78.0) | ||
| Tumor location | < 0.001 | |||
| Bone | 5556 (94.8) | 221 (82.5) | ||
| Extra-skeleton | 304 (5.2) | 47 (17.5) | ||
| Primary site | < 0.001 | |||
| Extremity | 4407 (75.2) | 80 (29.9) | ||
| Trunk | 1353 (23.1) | 175 (65.2) | ||
| Unknown | 100 (1.7) | 13 (4.9) | ||
| Histology | < 0.001 | |||
| Pagetic ostosarcoma | 72 (1.2) | 9 (3.4) | ||
| Non-Pagetic ostosarcoma | 1675 (28.6) | 48 (17.9) | ||
| NOS | 4113 (70.2) | 211 (78.7) | ||
| Stage | 0.024 | |||
| Localized | 1987 (33.9) | 76 (28.4) | ||
| Regional | 2331 (39.8) | 104 (38.8) | ||
| Distant | 1133 (19.3) | 58 (21.6) | ||
| Unstaged | 409 (7.0) | 30 (11.2) | ||
| Grade | 0.266 | |||
| I | 236 (4.0) | 4 (1.5) | ||
| II | 327 (5.6) | 15 (5.6) | ||
| III | 1064 (18.2) | 50 (18.7) | ||
| IV | 2051 (35.0) | 90 (33.6) | ||
| Unknown | 2182 (37.2) | 109 (40.7) | ||
Data are expressed as n (%) unless otherwise specified.