Table 3.
Significant associations between DNA methylation and MDD in male.
| Men | Women | Interactiona | Men and women | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| cpg | chr | Position | Nearest gene | Δ beta | p value | Δ beta | p value | p value | Δ beta | p value |
| cg10675453 | 6 | 41754588 | PRICKLE4 | 0.036 | 1.07E-09 | 0.003 | 0.2796 | 1.26E-09 | 0.013 | 1.92E-06 |
| cg25594636 | 1 | 207224388 | YOD1 | 0.023 | 4.58E-09 | 0.008 | 6.03E-05 | 0.0001 | 0.013 | 2.55E-11 |
| cg03899372 | 1 | 207224102 | YOD1 | 0.041 | 8.80E-09 | 0.010 | 0.0024 | 4.51E-06 | 0.020 | 3.12E-09 |
| cg17265120 | 17 | 42987382 | GFAP | −0.054 | 5.22E-08 | −0.006 | 0.3968 | 6.88E-05 | −0.021 | 0.0002 |
| cg22969689 | 5 | 96845117 | RP11-1E3.1 | −0.036 | 6.74E-08 | 0.000 | 0.8953 | 1.11E-07 | −0.011 | 0.0004 |
| cg00618087 | 17 | 16282382 | UBB | −0.049 | 6.79E-08 | 0.002 | 0.5535 | 1.54E-11 | −0.013 | 0.0009 |
Bonferroni threshold: 1.22e-07.
Adjusted for age at death, PMI, neuron subtype proportion and the first three principal components from the genotype data.
aInteraction between sex and MDD diagnosis is tested for each CpG site.
Δ beta: this coefficient represents the mean difference of DNA methylation beta values between participants with and without MDD. Negative coefficients refer to smaller mean DNA methylation beta values in participants with MDD and positive coefficients refer to larger mean DNA methylation beta values in participants with MDD.
Associations in men, women, and all participants are ordered by the p values from the analysis of male participants.