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. 2020 Jul 30;11(7):599. doi: 10.1038/s41419-020-02805-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Quantitative analysis of heart-to-body weight ratio (HW/BW) (n = 8–10 mice per group); b Quantitative analysis of lung-to-body weight ratio (LW/BW) (n = 8–10 mice per group); c left ventricular ejection fraction (LVEF, %) (n = 8–10 mice per group); d left ventricular fractional shortening (LVFS, %) (n = 8–10 mice per group); e hematoxylin-eosin (H&E, scale bar = 2 mm) staining; f wheat germ agglutinin (WGA, scale bar = 50 μm) staining; g quantitative analysis of cardiomyocyte cross-sectional areas (CSA) (n = 7–15 mice per group); h cardiomyocyte peak shortening (PS, normalized to resting cell length) (n = 300 cells per group); i maximal velocity of shortening (+dL/dt) (n = 300 cells per group); j maximal velocity of relengthening (−dL/dt) (n = 300 cells per group); k time-to-90% relengthening (TR90) in isolated cardiomyocytes (n = 300 cells per group). Mean ± SEM, *P < 0.05, **P < 0.01, ****P < 0.0001. Statistical analysis was carried out by a one-way ANOVA analysis followed by Tukey’s test for post hoc analysis.