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. 2020 Jul 30;11(7):599. doi: 10.1038/s41419-020-02805-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap of different groups in mRNA array; b three-dimensional diagram of mitophagy related genes when compared Sham+Control group with TAC + Control group; c volcano plot graphs of mPCR array. Graph shows the log2 of fold change of ALDH2 and FUNDC1 gene expression between Sham+Control group and TAC + Control group versus P value from the t test; d three-dimensional diagram of mitophagy related genes expression when compared TAC + Control group with TAC + LA group; e volcano plot graphs of mPCR array. Graph shows the log2 of fold change of ALDH2 and FUNDC1 gene expression between TAC + Control group and TAC + LA group versus P value from the t test; f correlation between FUNDC1 and ALDH2 expression in GTEx database; g Western blots of FUNDC1, LC3, P62, and β-actin (loading control); h–j quantitative analysis of expressions of FUNDC1/β-actin, LC3II/LC3I, P62/β-actin (n = 6 mice per group). Mean ± SEM, *P < 0.05, **P < 0.01. Statistical analysis was carried out by a two-tailed Student’s t test or one-way ANOVA analysis followed by Tukey’s test for post hoc analysis.