FIGURE 7.

Influence of XAF‐1407 on ECG parameters of AV nodal and ventricular electrophysiology: (a) influence on heart rate (HR) measured on four different time points (minutes) in relation to start of drug administration. (b) Mean difference in HR from before (T ₋₅) to end (T ₁₅) of drug injection at the different procedure days. (c) Change in P:QRS ratio prior to drug injection at resting heart rate (RHR; ~30–40 bpm), prior to drug injection at basic cycle length (BCL) 400 ms and 1 h after drug injection at BCL 400 measured at baseline before AF induction. (d) Influence on PR interval measured on four different time points (minutes) in relation to start of drug administration at baseline before AF induction. (e) Influence on QRS duration measured on four different time points (minutes) in relation to start of drug administration. (f) Influence on QTc measured on four different time points (minutes) in relation to start of drug administration. *P < .05, significantly different as indicated