Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 24;10:1225. doi: 10.3389/fonc.2020.01225

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Salvestrini, Ciciarello, Pensato, Simonetti, Laginestra, Bruno, Pazzaglia, De Marchi, Forte, Orecchioni, Martinelli, Bertolini, Méndez-Ferrer, Adinolfi, Di Virgilio, Cavo and Curti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Denatonium affects leukemia cell viability. (A) Western blot analysis of the denatonium-sensitive T2Rs in two AML cell lines and five AML samples (Pt). Actin was shown as the loading control. (B) Cell viability detected by CellTiter 96 Aqueous One Solution assay in AML samples (n = 7) and AML cell lines (n = 3 for each cell line) treated for 48 h with increasing doses of DEN. (C) Cell viability detected by CellTiter-Glo assay in THP-1 wild type and in T2R4, T2R8, T2R10, T2R13, and T2R30 knockout THP-1 (n = 3 for each cell line).