TABLE 1.

Thrombin effects on miRNA target genes and cellular processes.

MicroRNA (miRNA)	Thrombin-induced effects	microRNA target gene(s)	Cellular process	References
miR-181b	↓	CARD10	Endothelial cell activation	Lin et al., 2016
miR-181c	↓	MLL1	Microglia activation	Yin et al., 2017
miR-146	↑	CARD10	Endothelial cell activation	Cowan et al., 2014
miR-146a	↓	NOX4	Inflammation	Wang et al., 2014
miR-10b	↑	HOXD10	Angiogenesis	Shen et al., 2011
miR-let7c	↑	IGF-1R	Intracerebral hemorrhage	Kim et al., 2014
miR-27b	↓	TSP-1	Angiogenesis	Miao et al., 2018
miR-21	↑	WASp	Inflammation, Fibrosis	Li et al., 2017; Barwari et al., 2018
miR-339	↑	Klotho	Inflammation	Mehi et al., 2014; Li et al., 2017
miR-223	↑	IGF-1R	Inflammation Apoptosis	Pan et al., 2014; Li et al., 2017
miR-24-1-5p	↑	PHD1	Intracerebral hemorrhage	Cui et al., 2020
miR-25-3p	↑	ADAM10	Inflammation	Yao et al., 2019

ADAM10, a disintegrin and metalloproteinase domain-containing protein 10; CARD10, caspase recruitment domain-containing protein 10; HoxD10, homeobox D10; IGF-1R, insulin-like growth factor type 1 receptor; MLL1, mixed lineage leukemia protein-1; NOX4, NADPH oxidase 4; PHD1, prolyl hydroxylase domain 1; TSP-1, thrombospondin-1; WASp, Wiskott–Aldrich syndrome protein.