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The drug resistance mechanisms of EGFR monoclonal antibodies. Four classifications: (1) Pre-target: b, c, and m (KRAS mutation, the tumor microenvironment); (2) On-target: a and e (high expression of EGFR or ligand), f and g (mutation and deletion of extracellular domain binding site); (3) Post-target: j, k, l, m, o, and p (EGFR downstream signaling pathways); (4) Off-target: q, n, h, and I (Drug resistance factors associated with non-EGFR signaling molecules or receptors).
