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. 2020 Jul 24;8:655. doi: 10.3389/fcell.2020.00655

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Copyright © 2020 Sun, Wang, Wang, Yao, Li, Dong, Li, Li, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic reprogramming activates epithelial–mesenchymal transition (EMT)-inducing transcription factor and induces the EMT process to promote breast cancer metastasis and drug resistance. Glucose-6P, glucose 6-phosphate; fructose-6P, fructose 6-phosphate; fructose-1-6P, fructose-1-6-phosphate; PGI, phosphoglucose isomerase; FBP1, fructose-1,6-bisphosphatase 1; PKM2, pyruvate kinase M2; PDH, pyruvate dehydrogenase; PDK1, pyruvate dehydrogenase kinase 1; TCA cycle, tricarboxylic acid cycle; mt DNA, mitochondrial DNA; FAO, fatty acid oxidation; Gln, glutamine; GLS2, glutaminase 2; DG, diglyceride; TG, triglyceride; LA, linoleic acid; AA, arachidonic acid; PGH2, prostaglandin H2; PGF2α, prostaglandin F2α; LDs, lipid droplets; ACC, acetyl-coA carboxylase; FASN, fatty acid synthase; AKR1B1, aldo-keto reductase 1 member B1; Glu, glutamate; Asp, aspartate; Asn, asparagine; ASNS, asparagine synthetase; ROS, reactive oxidative stress; EMT-TF, epithelial–mesenchymal transition transcription factor.