Table 1.

mRNA Targets of miR-137 in Glioma Development and Function

Targets	Major Functions	References
LSD1	promoting NSC or GSC proliferation and inhibiting differentiation	25
EZH2	promoting proliferation and angiogenesis of glioma cells	58
RTVP-1	promoting GSCs’ self-renewal and inhibiting their differentiation	6
TCF4	binding to β-catenin and triggering Wnt/β-catenin signaling	61
CDK6	cell-cycle regulator	17
COX2	promoting glioma cell proliferation and invasion	41
EGFR	increasing cell growth and decreasing cell apoptosis	55
FOXK1	promoting proliferation and cell-cycle transition and inhibiting apoptosis	62
PDGFRα	increasing cell growth and reducing cell apoptosis	60
ZO-2	angiogenesis and blood tumor barrier permeability	28
CSE1L	inhibiting glioma cell proliferation, invasion	63
Msi1	promoting self-renewal, proliferation, tumorigenesis	60
RasGRF1	promoting glioma cell proliferation and inhibiting apoptosis	23
Rac1	promoting glioma cell proliferation and inhibiting apoptosis	50
CENPE	promoting pediatric high-grade glioma cell proliferation	45
PTP4A3	promoting GBM cell proliferation, migration, and invasion	64
SP1	promoting cell proliferation and invasion	30
FOXC1	angiogenesis and blood tumor barrier permeability	28
TRIM24	drug resistance	31
CAR	drug resistance	65
STC1	promoting metastasis and cell proliferation	57
CXCL12	promoting cell proliferation and invasion	54
NUCKS1	promoting cell proliferation and drug resistance	66
BCL2	inhibiting apoptosis	50
SLC1A5	regulating cell growth, survival, and proliferation	51

GBM, glioblastoma.