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. 2020 Jun 30;18:520–531. doi: 10.1016/j.omtm.2020.06.025

Figure 4.

Figure 4

In Vivo Off-target Validation on Liver DNA Samples

(A) NGS data of off-target sites for liver DNA samples isolated from adult mice 16 weeks after vector treatment. Cumulative indel mutations within the protospacer region were plotted for each off-target locus in the targeted group (n = 5) compared to untreated mice (n = 3). (B) NGS data of off-target sites for liver DNA samples isolated from newborn mice 14 weeks after vector treatment. Cumulative indel mutations within the protospacer region were plotted for each off-target locus in the targeted group (n = 5) compared to untreated mice (n = 3). Means ± SEM are shown.