Figure 5.

CD123-CAR^CD20 T Cells Have Potent Antitumor Activity In Vivo

(A) Schematic of experimental design. (B–E) Animals were intravenously injected with Molm13-expressing luciferase, followed by infusion of either 3 × 10⁶ or 1 × 10⁷ effector T cells and in vivo imaging for evaluation of tumor burden. (B) Bioluminescence signal over time (total flux in photons/s) of group receiving 1 × 10⁷ T cells. (C) Kaplan-Meier survival curves for animal groups receiving 1 × 10⁷ T cells. Statistical significance was determined with a Wilcoxon rank-sum test (p < 0.05; blue shading in table). (D) Bioluminescence signal over time (total flux in photons/s) of group receiving 3 × 10⁶ T cells. (E) Kaplan-Meier survival curves for animal groups receiving 3 × 10⁶ T cells. Statistical significance was determined by Wilcoxon rank-sum test (p < 0.05; blue shading in table).