Table 2.
Physiological values and levels of inflammatory cytokines during the experiment
| Variable | Group | 0 h | 3 h | 5 h |
|---|---|---|---|---|
| Temp (°C) | Prot-V | 37.4 ± 1.1 | 37.9 ± 1.3 | 37.8 ± 1.3 |
| Control | 37.6 ± 1.3 | 37.9 ± 1.5 | 37.9 ± 1.6 | |
| MAP (mmHg) | Prot-V | 91 ± 11 | 76 ± 23 | 63 ± 13 |
| Control | 92 ± 9 | 90 ± 19 | 71 ± 14 | |
| MPAP (mmHg) | Prot-V | 28 ± 9 | 40 ± 5 | 35 ± 7 |
| Control | 25 ± 8 | 38 ± 4 | 35 ± 7 | |
| CI (L x min− 1x m− 2) | Prot-V | 2.8 ± 0.5 | 1.8 ± 0.4 | 2.0 ± 0.5 |
| Control | 2.6 ± 0.5 | 2.3 ± 0.4 | 2.2 ± 0.5 | |
| Lactate (mmol x L−1) | Prot-V | 2.0 ± 0.8 | 2.6 ± 1.4 | 2.0 ± 1.0 |
| Control | 2.2 ± 1.0 | 2.7 ± 1.0 | 2.5 ± 1.0 | |
| LVSWI (gm x m−2 × beat) | Prot-V | 33 ± 9 | 16 ± 10 | 13 ± 5 |
| Control | 32 ± 8 | 21 ± 7 | 15 ± 6 | |
| Diuresis (mL x h−1) | Prot-V | 73 (34–190) | 25 (15–42) | 15 (10–20) |
| Control | 43 (0–110) | 85 (33–110) | 11 (4–15) | |
| PaO2/FiO2 (mmHg) | Prot-V | 478 ± 61 | 381 ± 107 | 368 ± 159 |
| Control | 473 ± 70 | 274 ± 100 | 219 ± 88 | |
| Trc (109x L−1) | Prot-V | 388 ± 104 | 281 ± 107 | 258 ± 100 |
| Control | 389 ± 93 | 280 ± 68 | 255 ± 93 | |
| PEEP (cmH2O) | Prot-V | 5.1 ± 0.2 | 10.2 ± 0.4 | 10.1 ± 0.4 |
| Control | 5.0 ± 0 | 5.0 ± 0 | 5.0 ± 0 | |
| P peak (cmH2O) | Prot-V | 20 ± 4 | 25 ± 5 | 26 ± 5 |
| Control | 20 ± 4 | 24 ± 3 | 25 ± 3 | |
| RR (min−1) | Prot-V | 31 ± 15 | 47 ± 11 | 49 ± 13 |
| Control | 20 ± 5 | 22 ± 3 | 23 ± 5 | |
| VE (L x min−1) | Prot-V | 5.8 ± 1.8 | 7.0 ± 1.8 | 7.5 ± 1.9 |
| Control | 5.3 ± 1.4 | 5.8 ± 1.1 | 6.1 ± 1.2 | |
| PaCO2 (kPa) | Prot-V | 5.2 ± 0.5 | 5.6 ± 0.6 | 5.5 ± 0.5 |
| Control | 5.1 ± 0.4 | 5.5 ± 0.7 | 5.6 ± 0.6 | |
| Leukocytes (109x L−1) | Prot-V | 9 ± 4 | 10 ± 8 | 8 ± 5 |
| Control | 10 ± 5 | 8 ± 5 | 7 ± 4 | |
| Neutrophils (109x L−1) | Prot-V | 3 ± 3 | 6 ± 8 | 5 ± 5 |
| Control | 4 ± 4 | 4 ± 4 | 4 ± 3 | |
| TNF (log10ng x L−1) | Prot-V | 3.3 ± 0.6 | 3.3 ± 0.2 | 3.0 ± 0.2 |
| Control | 3.1 ± 0.7 | 3.6 ± 0.5 | 3.2 ± 0.4 | |
| IL6 (log10ng x L−1) | Prot-V | 1.8 ± 0.4 | 2.4 ± 0.3 | 3.1 ± 0.2 |
| Control | 1.7 ± 0.5 | 2.6 ± 0.5 | 3.2 ± 0.3 | |
| IL10 (log10ng x L−1) | Prot-V | 1.9 ± 0.5 | 1.6 ± 0.2 | 1.6 ± 0.2 |
| Control | 2.0 ± 0.5 | 1.8 ± 0.4 | 1.8 ± 0.5 |
Group Prot-V (n = 20) and group Control (n = 10). Values are given as mean ± SD and median (interquartile range). MAP-mean arterial blood pressure, MPAP-mean pulmonary arterial pressure, CI-cardiac index, Lactate-arterial lactate, LVSWI-left ventricular stroke work index, PaO2/FiO2-ratio of arterial partial pressure of oxygen to fraction of inspired oxygen, P peak-peak intratracheal pressure, RR-respiratory rate, VE-expired minute ventilation, PaCO2-arterial partial pressure of carbon dioxide, TNF-α- arterial tumor necrosis factor alpha, IL-6-arterial interleukin 6, IL-10-arterial interleukin 10