Table 3.
Inhibition of SARS-CoV-2 3CLpro and PLpro by 28 compounds included in Shuanghuanglian oral liquids.
| Chemical name | Plant resource | 3CLpro | PLpro | ||||
|---|---|---|---|---|---|---|---|
| Inhibition (%) (μM) | IC50 (μM) | Inhibition (%) (μM) | |||||
| 100 | 10 | 50 | 12.5 | ||||
| 1 | Chlorogenic acid | L. japonica | 76.4 | 20.2 | 39.48 ± 5.51 | 12.5 | / |
| 2 | Neochlorogenic acid | 49.2 | 10.4 | / | 6.2 | / | |
| 3 | Cryptochlorogenic acid | 39.7 | / | / | 14.0 | / | |
| 4 | Isochlorogenic acid A | 77.0 | 18.9 | / | 18.7 | / | |
| 5 | Isochlorogenic acid B | 52.4 | 26.3 | / | 24.2 | / | |
| 6 | Isochlorogenic acid C | 78.2 | 18.4 | / | 11.0 | / | |
| 7 | 1,3-Dicaffeoylquinic acid | 87.3 | 27.8 | / | 14.4 | / | |
| 8 | Loganin | 10.6 | / | / | −1.7 | / | |
| 9 | Secoxyloganin | 4.6 | / | / | −13.0 | / | |
| 10 | Luteoloside | 65.4 | 14.8 | / | 21.5 | / | |
| 11 | Baicalin | S. baicalensis | 97.6 | 68.9 | 6.41 ± 0.95 | 15.9 | / |
| 12 | Baicalein | 99.4 | 87.0 | 0.94 ± 0.20 | 45.1 | 12.4 | |
| 13 | Wogonoside | 20.4 | / | / | 14.4 | / | |
| 14 | Wogonin | 3.6 | / | / | 52.0 | 35.9 | |
| 15 | Scutellarin | 76.8 | 18.9 | / | 41.8 | 12.7 | |
| 16 | Scutellarein | 101.6 | 90.7 | 3.02 ± 0.11 | 65.7 | 14.4 | |
| 17 | Oroxylin A-7-O-β-d-glucuronide | 33.0 | / | / | 7.4 | / | |
| 18 | Chrysin-7-O-β-d-glucoronide | 50.6 | 24.2 | / | 16.3 | / | |
| 19 | Phillyrin | F. suspensa | −18.1 | −2.8 | / | −1.2 | / |
| 20 | Phillygenin | 11.4 | / | / | 8.5 | / | |
| 21 | Forsythoside A | 95.3 | 70.5 | 3.18 ± 0.12 | 7.1 | / | |
| 22 | Forsythoside B | 101.4 | 80.9 | 2.88 ± 0.13 | 12.7 | / | |
| 23 | Forsythoside E | 96.6 | 41.9 | 6.68 ± 0.22 | −7.0 | / | |
| 24 | Forsythoside H | 99.3 | 61.7 | 10.17 ± 0.39 | 2.5 | / | |
| 25 | Forsythoside I | 95.9 | 46.3 | 5.47 ± 0.31 | 1.7 | / | |
| 26 | Isoforsythiaside | 94.4 | 46.8 | 5.85 ± 0.06 | 61.4 | 25.1 | |
| 27 | Acteoside | 97.0 | 34.6 | / | 15.6 | / | |
| 28 | (+)-Pinoresinol-4-O-β-d-glucopyraside | 13.3 | / | / | 8.0 | / | |
/ not detected.