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. 2020 Jul 30;10:12784. doi: 10.1038/s41598-020-69494-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Asthma regulatory networks demonstrate extensive alterations, with both increased and decreased transcription factor (TF) regulation strength. Regulatory strengths outputted from PANDA are displayed for several example TFs in two representative WGCNA modules (MHCI_1 and IL1). The y axis represents regulatory strength in the asthma network while the x axis represents regulatory strength in the control network. Each individual point represents the regulatory strength of the given TF on each of its gene targets in the representative modules. Points above and below the y = x line respectively indicate stronger regulation in asthma relative to controls, and controls relative to asthma.