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. 2020 Jul 30;10:12784. doi: 10.1038/s41598-020-69494-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcription factors (TFs) within the same regulatory communities bind in similar locations on differentially methylated regions (DMRs). Binding locations of TFs with binding motifs (based on 80% of maximum confidence) in a DMR in TNFSF13B. The TFs are separated based upon their regulatory cluster memberships as defined in Fig. 4.