Table 1.
WGCNA modules from tetanus toxoid-stimulated gene expression, with associated gene ontology (GO) annotations and high centrality genes.
| Module | GO annotations | Genes with high centrality in STRING PPI network |
|---|---|---|
| Mitos-1 | Mitotic nuclear division | CDC20, CDK2, BIRC5, PLK1, AURKA |
| Sister chromatid segregation | ||
| IL1 | Cellular response to IL-1 | HSP90AA1, BCL2, CASP3, UBE2N, CHUK |
| IL-1-mediated signaling | ||
| Protein modification by small protein removal | ||
| Mitos-2 | DNA replication | CDK1 , PRKCB, PCNA, TOP2A, BRCA1 |
| Chromosome segregation | ||
| Cell cycle checkpoint | ||
| Ig_rec | Somatic recombination of immunoglobulin genes involved in immune response | PARP1, MCM5, MCM7, POLA2, H2AFX |
| Somatic diversification of immunoglobulins involved in immune response | ||
| DNA-dependent DNA replication | ||
| MHCI-1 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | ACTA2, SF3B3, UBC, TUBG1, BCL3 |
| Tumor necrosis factor-mediated signaling pathway | ||
| Regulation of hematopoietic stem cell differentiation | ||
| LPS | Response to LPS | IL6, IL1B, LEP, SOCS3, IL1A |
| Response to molecule of bacterial origin | ||
| Positive regulation of VEGF production | ||
| MHCI-2 | Antigen processing and presentation of peptide antigen via MHC class I | STAT3, RUNX3, STAP2, AMER1, PIM2 |
| Positive regulation of NFkB signaling | ||
| Th2 | Humoral immune response mediated by circulating immunoglobulin | PDGFB , ITGB3, MMP1, NBEAL2, CCL13 |
| B cell mediated immunity | ||
| Adaptive immune response | ||
| Myel-1 | Neutrophil activation involved in immune response | CAT, LPL, TLR4, HSD17B4, ACSL1 |
| Positive regulation of macrophage derived from foam cell differentiation | ||
| Positive regulation of monocyte chemotaxis | ||
| Receptor-mediated endocytosis | ||
| Ifn-1 | Response to type 1 interferon | OAS1, ISG15, OASL, MX2, IRF7 |
| Defense response to virus | ||
| Metab | Lipid catabolic process | INSR, HSPA5, SDC2, PPARG, APOE |
| Myel-2 | Myeloid cell activation involved in immune response | TSPO, RHOA, JUN, RAC1, ICAM1 |
| Neutrophil degranulation | ||
| Neutrophil activation | ||
| Ifn-2 | Defense response to virus | DDX58, IFIH1, HERC5, STAT1, IFIT1 |
| Response to interferon-beta | ||
| Regulation of interferon-alpha production |