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. 2020 Jul 30;11:3825. doi: 10.1038/s41467-020-17506-9

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Center confocal slice and Mollweide projections of PfNCR1-GFP—EXP2-mRuby3 parasites. EXP2-mRuby3 (top, magenta), PfNCR1-GFP (middle, green), merge (bottom). Samples chosen represent examples of relatively low (0.48), average (−0.09) and high (−0.55) anti-correlation according to the Pearson correlation coefficients of the maps. The dotted line labels the equator, corresponds to the confocal slice. Scale bar: 1 µm. b Pearson correlation coefficients of EXP2-mNeonGreen—PV-mRuby3 parasites (N = 38 cells, see Fig. 3) in comparison to PfNCR1-GFP—EXP2-mRuby3 (N = 39 cells). Regions that extend from the parasite to form the tubulovesicular network were excluded for the correlation analysis. Bars: mean ± 95% CI. Both distributions are significantly different: P = 1.2 × 10⁻²⁹ (t-test, two tailed). c Localization of EXP2 correlates with the existence of a relatively large PV lumen. The PV lumen can store proteins for export and accessory proteins to facilitate protein export. The lipid transporter PfNCR1 localizes to regions of close PPM-PVM apposition. Functionally, PfNCR1 may be able to directly contact the PVM to exchange lipids and sites of membrane apposition may be sites for the general exchange of lipophilic material, a functional hallmark of membrane contact sites. Source data are provided as a Source data file.