Fig. 6. Impact of different strategies upon infection later in pregnancy in areas of high quintuple SP resistance.

Figure shows the impact of different simulated strategies upon the incidence of new (defined as either symptomatic or asymptomatic blood-stage) infection following a first ANC visit in the second trimester at 20 weeks gestation in areas of low, moderate and high transmission (EIRs of 1, 10 and 100). a Shows the percentage of women who will experience any new infection in the second or third trimester (T2/3), b shows the average number of new infections occurring throughout T2/3. Each strategy is assumed to involve three scheduled ANC visits occurring at 20, 27 and 34 weeks, except for “Monthly DP” (darkest blue) which involves five visits spaced 30 days apart from 20 weeks onwards. A perfect test refers to a hypothetical diagnostic with perfect sensitivity and specificity for peripheral or placental infection. Error bars show 95% intervals based upon our uncertainty analysis for comparing the relative impact of intervention strategies (see “Methods” section).