Table 1.
Systemic Invasive Hemodynamics Data
| 60 Min of Ischemia |
75 Min of Ischemia |
|||||
|---|---|---|---|---|---|---|
| Vehicle (n = 7) | HNG (2 mg/kg) (n = 7) | p Value | Vehicle (n = 9) | HNG (2 mg/kg) (n = 10) | p Value | |
| Baseline | ||||||
| Systolic blood pressure (mm Hg) | 129 ± 5.3 | 116.0 ± 4.9 | 0.096 | 126 ± 6.3 | 128 ± 5.4 | 0.831 |
| Diastolic blood pressure (mm Hg) | 96 ± 4.8 | 79.0 ± 2.3 | 0.008 | 91 ± 6.4 | 91.4 ± 4.2 | 0.981 |
| Mean arterial blood pressure (mm Hg) | 112 ± 4.9 | 96.7 ± 3.3 | 0.022 | 109 ± 6.3 | 108 ± 4.7 | 0.984 |
| 45-min occlusion | ||||||
| Systolic blood pressure (mm Hg) | 123 ± 9.9 | 101.0 ± 9.9 | 0.085 | – | – | – |
| Diastolic blood pressure (mm Hg) | 92 ± 8.3 | 81.0 ± 7.7 | 0.291 | – | – | – |
| Mean arterial blood pressure (mm Hg) | 107 ± 6.2 | 84.0 ± 11.3 | 0.088 | – | – | – |
| 60-min occlusion | ||||||
| Systolic blood pressure (mm Hg) | – | – | – | 109 ± 8.6 | 111 ± 6.4 | 0.869 |
| Diastolic blood pressure (mm Hg) | – | – | – | 86 ± 5.7 | 92 ± 6.5 | 0.514 |
| Mean arterial blood pressure (mm Hg) | – | – | – | 96 ± 6.2 | 100 ± 6.8 | 0.687 |
| 15-min reperfusion | ||||||
| Systolic blood pressure (mm Hg) | 111 ± 8.7 | 108.0 ± 10.3 | 0.808 | 98 ± 8.7 | 100 ± 6.0 | 0.837 |
| Diastolic blood pressure (mm Hg) | 79 ± 8.3 | 76.0 ± 8.7 | 0.741 | 78 ± 7.5 | 78 ± 5.4 | 0.916 |
| Mean arterial blood pressure (mm Hg) | 95 ± 5.9 | 91.0 ± 9.5 | 0.740 | 87 ± 8.2 | 88 ± 6.4 | 0.907 |
| 48-h reperfusion | ||||||
| Systolic blood pressure (mm Hg) | 106 ± 5.9 | 108.0 ± 7.0 | 0.809 | 84 ± 6.6 | 93 ± 4.3 | 0.328 |
| Diastolic blood pressure (mm Hg) | 70 ± 7.6 | 69.0 ± 5.0 | 0.903 | 56 ± 5.3 | 66 ± 3.7 | 0.131 |
| Mean arterial blood pressure (mm Hg) | 86 ± 4.1 | 85.0 ± 5.8 | 0.912 | 71 ± 6.4 | 80 ± 4.3 | 0.284 |
Values are mean ± SD. The p value is between groups at time point for given measurement.
HNG = S14G-humanin.