Table 1.
Lesion Anatomical and Inflammation Measures, and Cholesterol and CRP Levels for DCB-PTA, PTA, and Sham-PTA Groups
| DCB-PTA (n = 10) | PTA (n = 10) | Sham-PTA (n = 5) | p Value | |
|---|---|---|---|---|
| Total atheroma volume (mm3) | ||||
| 6 weeks | 165.6 (31.0) | 145.6 (21.7) | 137.0 (16.4) | 0.348 |
| 10 weeks | 142.1 (45.1) | 237.5 (32.0) | 302.8 (164.3) | <0.001∗ |
| Δ Change | −19.7 (4.6) | 98.0 (64.7) | 183.6 (155.5) | <0.001∗ |
| Percent atheroma volume (%) | ||||
| 6 weeks | 16.0 (4.4) | 14.3 (5.1) | 12.8 (5.1) | 0.136 |
| 10 weeks | 14.0 (4.3) | 21.1 (3.7) | 19.5 (6.6) | 0.001† |
| Δ Change | −3.0 (4.6) | 5.7 (4.1) | 9.6 (1.4) | 0.001† |
| Average plaque burden (%) | ||||
| 6 weeks | 16.2 (5.5) | 14.2 (4.9) | 12.9 (5.2) | 0.179 |
| 10 weeks | 14.6 (5.3) | 19.9 (4.2) | 19.7 (6.3) | 0.009† |
| Δ Change | -2.5 (7.6) | 5.8 (4.0) | 9.8 (1.0) | 0.004† |
| Minimal lumen area (mm2) | ||||
| 6 weeks | 5.5 (2.1) | 6.3 (1.9) | 6.6 (1.7) | 0.600 |
| 10 weeks | 7.0 (1.3) | 7.9 (1.9) | 7.5 (3.0) | 0.379 |
| Δ Change | 1.1 (3.1) | 0.7 (2.0) | 2.6 (3.9) | 0.944 |
| Percent area stenosis, average (%) | ||||
| 6 weeks | 26.9 (6.9) | 23.4 (4.5) | 27.6 (9.1) | 0.417 |
| 10 weeks | 21.1 (5.6) | 21.9 (7.4) | 27.6 (10.4) | 0.392 |
| Δ Change | −5.2 (4.0) | −1.2 (2.1) | 0.0 (0.5) | <0.001∗ |
| NIRF inflammation, average (nM) | ||||
| 6 weeks | 17.8 (10.2) | 19.6 (3.9) | 17.6 (10.1) | 0.818 |
| 10 weeks | 40.2 (43.5) | 63.4 (45.7) | 63.5 (57.9) | 0.092 |
| Δ Change | 18.3 (43.8) | 44.6 (35.5) | 48.4 (47.6) | 0.100 |
| Total cholesterol (mg/dl) | ||||
| 6 weeks | 1,654.0 (691.0) | 2,153.0 (867.0) | 1,967.0 (79.0) | 0.304 |
| 10 weeks | 439.5 (310.0) | 572.5 (634.0) | 214.0 (133.0) | 0.051 |
| Δ Change | −1,082.0 (382.0) | −1,620.0 (759.0) | −1,668.0 (756.0) | 0.394 |
| CRP (ng/ml) | ||||
| 6 weeks | 19.4 (8.0) | 26.8 (12.6) | 9.6 (6.4) | 0.017‡ |
| 10 weeks | 22.7 (29.7) | 24.6 (51.9) | 10.5 (7.7) | 0.038‡ |
| Δ Change | −0.4 (31.1) | 1.7 (6.6) | −1.7 (6.3) | 0.650 |
Values are median (interquartile range).
Plaque area measurement obtained using intravascular ultrasound (IVUS). All 6-week imaging measures were obtained from IVUS or near-infrared fluorescence-optical coherence tomography (NIRF-OCT) images collected before drug-coated balloon percutaneous transluminal angioplasty (DCB-PTA), PTA, or sham-PTA.
CRP = C-reactive protein.
∗
p < 0.001;
†
p < 0.01;
‡
p < 0.05.