Table 1.

Association of 10 Independent SNPs at the PCSK9 Locus and of a wGRS With Natural Log-Transformed Lipoprotein-Lipid Levels in 9,692 Participants of the EPIC-Norfolk Study

	TC	p Value∗	LDL-C	p Value∗	HDL-C	p Value∗	VLDL-C	p Value∗	TG	p Value∗	apoB	p Value∗	apoA-I	p Value∗	Lp(a)	p Value∗
rs585131	−1.2 (0.75)	0.092	−1.3 (0.69)	0.046	−0.017 (0.0068)	0.013	0.11 (0.28)	0.738	3.8 (1.3)	0.003	−0.0047 (0.0043)	0.248	−0.0051 (0.0055)	0.269	−0.27 (0.43)	0.877
rs2483205	−0.15 (0.60)	0.764	−0.52 (0.55)	0.352	0.00013 (0.0054)	0.971	0.37 (0.22)	0.089	1.9 (1.0)	0.064	−0.0010 (0.0034)	0.949	0.0046 (0.0043)	0.333	−0.086 (0.34)	0.901
rs2479394	−0.41 (0.69)	0.541	−0.79 (0.63)	0.201	0.012 (0.0062)	0.088	0.37 (0.25)	0.173	−0.32 (1.2)	0.906	−0.0088 (0.0039)	0.033	0.0077 (0.0050)	0.135	−0.42 (0.39)	0.909
rs10493176	−2.2 (1.1)	0.037	−2.0 (0.97)	0.043	0.00082 (0.0096)	0.958	−0.18 (0.39)	0.520	−1.2 (1.8)	0.579	−0.0060 (0.0060)	0.540	0.014 (0.0077)	0.042	−0.72 (0.60)	0.410
rs11206510	−1.7 (0.74)	0.011	−1.2 (0.68)	0.029	−0.0099 (0.0067)	0.101	−0.46 (0.27)	0.053	−0.65 (1.3)	0.660	−0.0051 (0.0042)	0.213	−0.0016 (0.0054)	0.805	−0.19 (0.42)	0.952
rs2479409	−1.6 (0.64)	0.010	−1.7 (0.58)	0.003	0.0030 (0.0057)	0.590	0.12 (0.23)	0.557	−0.024 (1.1)	0.613	−0.0024 (0.0036)	0.698	0.011 (0.0046)	0.014	−0.17 (0.36)	0.669
rs12067569	−0.33 (1.8)	0.866	−1.9 (1.7)	0.189	0.016 (0.017)	0.363	1.6 (0.68)	0.021	4.4 (3.1)	0.052	0.0057 (0.010)	0.767	0.013 (0.013)	0.372	−0.85 (1.0)	0.381
rs10888896	−1.8 (0.69)	0.0057	−2.0 (0.63)	<0.001	−0.0046 (0.0062)	0.489	0.18 (0.25)	0.459	1.9 (1.2)	0.503	−0.0039 (0.0039)	0.413	1.9e−05 (0.0050)	0.711	−0.44 (0.39)	0.600
rs11591147	−19.8 (2.5)	<0.001	−18.2 (2.3)	<0.001	−0.030 (0.023)	0.183	−1.6 (0.92)	0.035	−2.6 (4.3)	0.602	−0.068 (0.014)	<0.001	−0.0042 (0.018)	0.888	−0.33 (1.4)	0.585
rs7552841	−2.8 (0.62)	<0.001	−2.5 (0.57)	<0.001	−0.0037 (0.0056)	0.514	−0.32 (0.23)	0.146	−0.81 (1.1)	0.476	−0.0093 (0.0035)	0.022	−0.0015 (0.0045)	0.837	−0.23 (0.35)	0.742
wGRS	−16.9 (2.4)	<0.001	−16.5 (2.2)	<0.001	−0.027 (0.022)	0.190	−0.41 (0.90)	0.463	2.9 (4.1)	0.369	−0.056 (0.014)	<0.001	0.018 (0.018)	0.202	−1.7 (1.4)	0.435

Values are beta (SE). All associations were adjusted for age and sex.

apoA-I = apolipoprotein A-I; apoB = apolipoprotein B; Lp(a) = lipoprotein(a); HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; SNP = single nucleotide polymorphisms; TC = total cholesterol; TG = triglycerides; VLDL-C = very-low-density lipoprotein cholesterol.

^∗Level of statistical significance was set as 0.00625 (0.05/8 lipid traits) on log-transformed values.