Figure 1.

HF Model

Representative cardiac magnetic resonance images (cMRIs) and apex histology for control animals and animals with heart failure (HF) as well plasma neurohumoral markers and myocardial atrial natriuretic peptide/B-type natriuretic peptide (ANP/BNP) expression and content. (A) Left ventricular (LV) end-diastolic and end-systolic contour and corresponding histological sections of myocardium from the apical region in (upper panel) control animals and (bottom panel) animals with HF, respectively. (B) Plasma neurohumoral markers (i.e., ANP, N-terminal proBNP [NT-proBNP], renin, and creatinine), following myocardial infarction (MI) of the HF group. (C) Myocardial ANP/BNP expression patterns and content of the control animals and animals with HF according to different myocardial regions. Relative expression of ANP and BNP and peptide concentrations are displayed as Tukey boxplots. LA = left atrium; MI = myocardial infarction; RA = right atrium; RV = right ventricle.