Table 2.

Numerical Values of NEP Expression, NEP Concentrations, and NEP activity in HF and Control Animals

	NEP Expression (Relative Expression)				NEP Content (ng NEP/mg Protein)			NEP Activity (nmol/mg Protein/min)
	HF Animals		Control Animals	p Value∗	HF Animals	Control Animals	p Value∗	HF Animals	Control Animals	p Value∗
LV myocardium	0.03 (0.03−0.07)	'0.04 (0.03-0.05)		0.013	166 (154−235)	613 (337−676)	0.003	0.09 (0.00−0.18)	0.37 (0.35−0.40)	0.005
Kidney	6.40 (6.19−8.11)		10.79 (9.31−15.12)		27,419 (18,881−27,510)	31,192 (16,787−51,268)		22.60 (18.35−27.54)	44.84 (23.42−46.69)
Lung	0.34 (0.31−0.67)		0.71 (0.62−0.84)		225 (198−271)	542 (541−591)		0.24 (0.20−1.02)	1.02 (0.78−1.41)
Liver	0.07 (0.00−0.19)		0.02 (0.01−0.02)		1,039 (889−1,330)	1.264 (1,111−1,689)		0.00 (0.00−0.21)	0.30 (0.25−0.30)
Duodenum	0.58 (0.36−1.62)		1.93 (1.75−2.07)		263 (233−263)	327 (293−412)		0.67 (0.47−0.72)	0.65 (0.64−0.73)
Brain	0.02 (0.01−0.02)		0.05 (0.04−0.10)		320 (238−470)	380 (366−869)		0.03 (0.02−0.14)	0.04 (0.00-0.07)

Values are median (25th to 75th percentile).

Pooled values were compared using the Mann-Whitney U test.

NEP = neprilysin; other abbreviations as in Table 1.

^∗The p value was calculated for the comparison of pooled samples between HF and control animals