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. Author manuscript; available in PMC: 2021 Jan 9.
Published in final edited form as: Adv Cancer Res. 2020 Jul 9;148:69–146. doi: 10.1016/bs.acr.2020.05.002

Figure 1. RAS structure.

Figure 1.

Alignment of RAS isoforms. Secondary structure is indicated by the location of alpha helices and beta strands. PTMs to specific residues are indicated as follows: farnesylation, (F); ubiquitylation and acetylation, (U); nitrosylation and glutationylation, (N); SUMOylation, (S); and Ca2+ binding, (C); phosphorylation, boxed residues (O); mutation hotspots,orange arrowheads (▲). Additionally, the dimer interface (α4-β6-α5) in highlighted.