Figure 6. Comparative structures of KRAS(G12C) inhibitors.
(A) Shokat cmpd 16 (PDB: M422); (B) ARS1620 (PDB:5V9U); (C) MRTX cmpd12 (PDB: 6N2K); (D) AMG510 (PDB: 6OIM). Coloring is the same as described in Fig. 2A
(A) Shokat cmpd 16 (PDB: M422); (B) ARS1620 (PDB:5V9U); (C) MRTX cmpd12 (PDB: 6N2K); (D) AMG510 (PDB: 6OIM). Coloring is the same as described in Fig. 2A