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. 2020 Jul 30;11(7):598. doi: 10.1038/s41419-020-02769-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The expression of circRNF121 was identified after transfection of various sicircRNAs by q-PCR. The RNF121 expression was detected by q-PCR in treated chondrocytes. b Representative proteins, MMP-13, ADAMTS-5, type II collagen, and aggrecan were analyzed in treated chondrocytes by western blot. c, d Ki-67 immunofluorescence staining and CCK-8 proliferation assay were used to identify the proliferative capability of chondrocytes after transfecting with circRNF121 or sicircRNA-2. e Apoptosis of chondrocytes was evaluated by flow cytometry. Viable and nonviable apoptotic cells are regarded as apoptotic cells. f Cleaved caspase-3 and PARP levels were measured by western blot. Data were means ± SD of three independent assays (*P < 0.05).