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. 2020 Jul 30;11(7):597. doi: 10.1038/s41419-020-02801-6

Fig. 6. Overexpression of miR-1224-5p inhibits tumour growth in vivo.

Fig. 6

a–f KYSE150 and KYSE510 cells transfected with negative control vector or miR-1224-5p-OE vector were inoculated into mice subcutaneously. Then, tumour growth, tumour volume and tumour weight were examined in different groups. g, h Immunohistochemical staining of TNS4 and VEGFA in subcutaneous tumour tissues. Scale bar = 50 μm. i–k qRT-PCR was used to evaluate the expression of miR-1224-5p, TNS4, EFNA1 and VEGFA in subcutaneous tumour tissues of different groups. l The ESCC dataset from GSE53622 was used to analyse the correlation in mRNA level between TNS4 and VEGFA. Data are represented as the mean ± SD; * p < 0.05; ** p < 0.01; *** p < 0.001.