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. 2020 Jul 30;11:3819. doi: 10.1038/s41467-020-17644-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Tumor-free survival (TFS), overall survival (OS) and time-to-death (TTD) of WT C57BL/6 mice (a, b) and Rag2^−/−Il2rg^−/− mice (a) or Ifng^−/− mice (b) subjected to M/D-driven oncogenesis. Number of mice, hazard ratio (HR) and p values (two-sided log-rank) are reported. c–e. Variations in TFS (c), OS (d) and TTD (e) imposed to M/D-driven oncogenesis in mice by the indicated genotype or immunomodulatory interventions. Results are means ± SEM plus individual data points. Number of mice, HR and p values (two-sided log-rank and one way-ANOVA plus Fisher LSD, calculated with respect to individual control experiments) are reported. Green dots indicate mice that were free of disease (c) and alive (d) at the end of the experiment. f–h TFS and OS of WT C57BL/6 (f–h) mice and Rag2^−/− BALB/c mice (f), C57BL/6 mice receiving NKG2D-depleting antibodies (g), or C57BL/6 mice receiving CD4- and CD8-depleting antibodies (h). Number of mice, HR and p values (two-sided log-rank) are reported.