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. 2020 Jul 30;11:3819. doi: 10.1038/s41467-020-17644-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Tumor-free survival (TFS), overall survival (OS) and time-to-death (TTD) of C57BL/6 mice subjected to M/D-driven oncogenesis in control conditions (a, b) or in the context of weekly 24-h-fasting episodes (a) or NAM supplementation with the drinking water (b). Number of mice, hazard ratio (HR) and p values (two-sided log-rank) are reported. c–e Variations in TFS (c), OS (d) and TTD (e) imposed to M/D-driven oncogenesis in C57BL/6 mice by the indicated nutritional interventions. Results are means ± SEM plus individual data points. Number of mice, HR and p values (two-sided log-rank and one way-ANOVA plus Fisher LSD, calculated with respect to individual control experiments) are reported. Green dots indicate mice that were free of disease (c) and alive (d) at the end of the experiment. HFD high-fat diet, HSD high sucrose diet, NR nicotinamide riboside.