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. 2020 Jul 30;11:3819. doi: 10.1038/s41467-020-17644-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–c Tumor growth and overall survival (OS) in C57BL/6 mice bearing established M/D-driven tumors that were maintained in control conditions (a–c) or subjected to NAM supplementation with the drinking water alone (a–c), or in the context of CD4⁺ and CD8⁺ T cell co-depletion (a), NK cell depletion (b), or IFNG neutralization (c). Tumor growth results are means ± SEM. Number of mice, hazard ratio (HR) and p values (two-way ANOVA corrected for row (time) and column (treatment) factors for tumor growth and two-sided log-rank for OS). Please note that NAM-treated tumors (red curves) in (a–c) are from the same experiment, also depicted in (d). d, e Tumor growth and OS in C57BL/6 (d) or BALB/c (e) mice bearing established M/D-driven (d) or TSA (e) tumors that were maintained in control conditions or subjected to NAM supplementation with the drinking water or systemic PD-1 blockage, alone or in combination. Tumor growth results are means ± SEM. Number of mice, hazard ratio (HR) and p values (two-way ANOVA corrected for row (time) and column (treatment) factors for tumor growth and two-sided log-rank for OS). Please note that NAM-treated tumors (red curves) in (d) are from the same experiment depicted in (a–c).