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. 2020 Jul 30;11(7):604. doi: 10.1038/s41419-020-02804-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The expression of EN1 (left) and EN2 (right) in CRC samples in GSE9348 dataset. b The expression of EN2 in CRC samples in GTEx and TCGA dataset. c, d The expression of EN2 analyzed by qRT-PCR (b) and western blotting (c) in CRC samples and adjacent normal colorectal samples. e, f The expression of EN2 analyzed by qRT-PCR (d) and western blotting (e) in 8401 and CRC cell lines. g The protein expression of EN2 detected by immunohistochemistry (IHC) in CRC and adjacent normal colorectal samples. Right is the quantification data for IHC. Top: original magnification, ×100. Scale bar: 100 µm; Bottom: original magnification, ×200. Scale bar: 50 µm. h Kaplan–Meier analysis of the overall survival rate of 165 CRC patients with low or high expression level of EN2. i Univariate and multivariate Cox regression analysis of different prognostic factors in CRC patients. j Receiver operating characteristic (ROC) curves for detecting CRC patients in GSE9348. Data are presented as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significance.