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. 2020 Jul 30;11(7):603. doi: 10.1038/s41419-020-02788-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Th17 cell differentiation in vitro after treated by 50 ng/ml control or IFN-γ-primed-MSC exosomes for 3–4 days, assessed by flow cytometry. c RORγt and IL-17 expression in Th17 cells, analyzed by qPCR. d, e Treg cell differentiation in vitro after treated by 50 ng/ml control or IFN-γ-primed-MSC exosomes for 3–4 days, assessed by flow cytometry. f Foxp3 and IL-10 expression in Treg cells, analyzed by qPCR. *P < 0.05, **P < 0.01, ***P < 0.001 Exo exosomes; IFN-γ Exo exosomes derived from IFN-γ-primed MSCs.