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. 2020 Jul 30;11(7):603. doi: 10.1038/s41419-020-02788-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The expression of p-Stat3 and Stat3 in T cells after IL-6 stimulation with or without 50 ng/ml exosomes treatment, as assessed by western blot. b The expression of p-Stat3 and Stat3 in T cells with the treatment as indicated. c Th17 cell differentiation treated by miR-125a (20 nmol), miR-125b (20 nmol), or miR-125a and miR-125b combination mimics for 3–4 days, analyzed by flow cytometry. d The expression of RORγt and IL-17 in Th17 cells in control, miR-125a, miR-125b, or miR-125a and miR-125b combination mimics treatment groups, analyzed by qPCR. e Treg cell differentiation treated by miR-125a (20 nM), miR-125b (20 nM), or miR-125a and miR-125b combination mimics, as assessed by flow cytomotry. f The expression of Foxp3 and IL-10 in in control, miR-125a, miR-125b, or miR-125a and miR-125b combination mimics treatment groups, as assessed by qPCR. Exo exosomes, NC negative control miRNA. *P < 0.05, **P < 0.01, ***P < 0.001.