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. 2020 Jul 30;11(7):603. doi: 10.1038/s41419-020-02788-0

Fig. 7. The schema of exosomes derived MSCs to attenuate colitis.

Fig. 7

Mice colitis could be ameliorated by MSC exosomes infusion, which transferred the miR-125a and miR-125b to T cells targeting on Stat3 to inhibit Th17 cell differentiation. IFN-γ pretreatment to MSCs promoted the levels of miR-125a and miR-125b in exosomes to elevate their therapeutic effects.