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. 2020 Jul 30;10:12851. doi: 10.1038/s41598-020-69773-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Frequencies and reporting odds ratios (RORs) of depression events. (a) Frequencies of depression events for patients administered botulinum toxin for cosmetic use (BoNT N = 20,684, control N = 1,214), migraine (BoNT N = 4,180, control N = 56,675), spasms and spasticity, excluding facial muscles (BoNT N = 2,335, control N = 45,824), torticollis (BoNT N = 1,360, control N = 6,765), blepharospasm (BoNT N = 487, control N = 153), hyperhidrosis (BoNT N = 601, control N = 712), sialorrhea (BoNT N = 157, control N = 1,174), neurological and urinary bladder disorders (BoNT N = 915, control N = 30,827). (b) Reporting odds ratios were calculated comparing frequencies of depression reports in patients administered botulinum toxin for each indication and respective control sub-cohorts. Ranges represent 95% confidence intervals (95% CI) (see “Methods”). BoNT botulinum toxin, AE adverse event, ROR reporting odds ratios.