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. 2020 Mar 12;18(1):65–71. doi: 10.1016/j.gpb.2020.02.001

Figure 1.

Figure 1

MND model of polymerase slippages

A. Allele length distribution of homopolymers in normal samples. The gray vertical lines represent the repeat lengths in the human reference genome (GRCh38). B. The fitness of the MND model for polymerase slippages. The values on the top of boxplots represent the percentages of sites fitted (P < 0.05, Kolmogorov–Smirnov test) to the MND model at the respective repeat lengths. C. Dot plots for the means of parameter p (probability of deletion) in the MND model using 326 MSI and 1206 MSS samples (11,666 sites). D. Dot plots for the means of parameter q (probability of insertion) in the MND model using 326 MSI and 1206 MSS samples (11,666 sites). Dots are color-scaled according to the number of sites as shown by the color key. Dots near the diagonal lines represent sites undistinguishable between MSI and MSS. MND, multinomial distribution; MSI, microsatellite instability; MSS, microsatellite stable.