Table 1.
AUC obtained using four MSI detection methods for 1532 samples from TCGA
| Method | Input | CRC (n = 588) | STAD (n = 412) | UCEC (n = 532) | Total (n = 1532) |
|---|---|---|---|---|---|
| MANTIS | T–N | 0.983 | 1.000 | 0.993 | 0.986 |
| MSIsensor | T–N | 0.981 | 1.000 | 0.988 | 0.989 |
| mSINGS | T | 0.594 | 0.711 | 0.634 | 0.594 |
| MSIsensor-pro (all) | T | 0.993 | 0.999 | 0.987 | 0.993 |
| MSIsensor-pro (DMS) | T | 0.997 | 1.000 | 0.990 | 0.994 |
Note: For MSIsensor-pro (all), all 11,666 preselected microsatellite sites were used for MSI computation; for MSIsensor-pro (DMS), only 7698 DMS sites were used for MSI computation. AUC, area under the receiver operating characteristic curve; DMS, discriminative microsatellite; CRC, colorectal cancer; STAD, stomach adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; T–N, tumor–normal paired sample; T, tumor only sample.