Figure 2.

Distribution profile of m⁵C in the lung tissues of FA- and PM2.5-exposed mice

A. Bar chart illustrating the expression levels of NOP2/Sun RNA methyltransferase family protein members in lungs of FA- and PM_2.5-exposed mice, as examined by RNA-Seq. FDR values calculated using Benjamini–Hochberg method were labeled on top of the genes. B. Bar chart showing the numbers of m⁵C sites and m⁵C-modified mRNAs lung samples of FA- and PM_2.5-exposed mice. C. Boxplots showing the overall distributions of mRNA m⁵C levels in lung samples of FA- and PM_2.5-exposed mice using meRanTK. The P values were calculated using two-sided Wilcoxon and Mann–Whitney tests. D. IGV tracks displaying the distributions of m⁵C methylation level (in the range of 0.0–1.0) on chromosome 2 in lung samples of FA- and PM_2.5-exposed mice. FDR, false positive rate; IGV, Integrative Genomics Viewer.