Table. Hearing Impairment Severity for All Survivors of Childhood Cancer by Treatment Exposure.
| Hearing sensitivity | No. (%) | |||
|---|---|---|---|---|
| Total survivors (N = 1520) | Treatment exposure group | |||
| No exposurea (n = 740) | Platinum-only exposureb (n = 307) | Cochlear RT exposurec (n = 473) | ||
| Normal hearing (Chang grade 0)d | 946 (62.2) | 621 (84.0) | 138 (45.0) | 187 (39.5) |
| Mild hearing impairment (Chang grades 1a, 1b, 2a)d | 221 (14.5) | 54 (7.3) | 62 (20.2) | 105 (22.2) |
| Severe hearing impairment (Chang grades 2b, 3, 4)d | 353 (23.2) | 65 (8.8) | 107 (34.9) | 181 (38.3) |
Abbreviation: RT, radiotherapy.
a
No exposure group (n = 740) comprised survivors who were not treated with platinum-based chemotherapy or cochlear RT.
b
Platinum-only exposure group (n = 307) comprised survivors who were treated with cisplatin and/or carboplatin chemotherapy.
c
Cochlear RT exposure group (n = 473) comprised survivors who were treated with cochlear RT with or without platinum-based chemotherapy.
d
Chang Ototoxicity Grading Scale range: (0-4, with the highest grade indicating the most severe hearing impairment).