Table 1.

Inhibitors of Nav1.5.

Inhibitor	Type	Effects on cancer cells	Mechanism	References
NESOpb/E3Ab	Antibodies	Reduce migration and invasion	Specifically inhibit NaV1.5	Brackenbury et al. (2007) Gao et al. (2019)
Phenytoin	Antiarrhythmic and antiepileptic agent	Reduce mobility migration and invasion	Inhibit Na+ currents down-regulate EGF expression and ERK1/2 phosphorylation reduce activity of MP-7, cathepsin E and kallikrein-10	Yang et al. (2012) Mohammed et al. (2016) Nelson et al. (2015a)
DAPT	Notch signal inhibitor	Reduce proliferation lateral motility	Increase the level of Notch4mRNA and decreased the ratio of MMP9 to TIMP1	Aktas et al. (2015)
DHA	ω-3 LC-PUFA	Reduce migration and invasion	Inhibit the expression of PPARβ and downregulate SCN5A expression and activity of NHE-1	Isbilen et al. (2006) Wannous et al. (2015)
Ranolazine	Antiarrhythmic drug	Reduce invasion	Decreases Na+ influx and ECM degradative activity	Driffort et al. (2014)
Taxol	Anticancer drug	Decrease invasion	Left shift of NaV1.5 activation and affect microtubule polymerization	Tran et al. (2009)
FS50	Animal salivary protein	Reduce migration and invasion	Decrease the expression of NaV1.5 mRNA level and distribution of NaV1.5 protein in the cell membrane	Zhang et al. (2018)
Compounds	Synthetic substances	Reduce the invasion	Block Nav1.5 channel	Dutta et al. (2018)
Propranolol	β‐AR blocker	Reduce migration and invasion	Affect the properties and expression of Nav1.5	Lee et al. (2019)