TABLE 3.

Genotype frequencies for the longitudinal and cross-sectional cohorts

			FT females n = 200	Frequent FT females n = 114	HI females n = 92	FT males n = 200	Deferred males n = 33	HI males n = 136
Longitudinal cohort	HFE C282Y	Wild type	180 (90%)	185 (93%)	103 (90%)	27 (82%)	80 (87%)	124 (91%)
		Heterozygous	20 (10%)	14 (7%)	11 (10%)	6 (18%)	12 (13%)	12 (9%)
		Homozygous	0 (0%)	1 (1%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
	HFE H63D	Wild type	142 (71%)	141 (71%)	81 (71%)	25 (76%)	67 (73%)	104 (76%)
		Heterozygous	53 (27%)	58 (29%)	32 (28%)	8 (24%)	23 (25%)	31 (23%)
		Homozygous	5 (3%)	1 (1%)	1 (1%)	0 (0%)	2 (2%)	1 (1%)
	TMPRSS6 A736V	Wild type	81 (41%)	33 (29%)	27 (29%)	79 (40%)	9 (27%)	40 (29%)
		Heterozygous	86 (43%)	62 (54%)	49 (53%)	82 (41%)	14 (42%)	61 (45%)
		Homozygous	33 (17%)	19 (17%)	16 (17%)	39 (20%)	10 (30%)	35 (26%)
			FT females n = 2055	Frequent FT females n = 762	HI females n = 788	FT males n = 1713	Deferred males n = 180	HI males n = 1575
Cross-sectional cohort	HFE C282Y	Wild type	1923 (87.5%)	687 (85.1%)	693 (84.7%)	1600 (88.9%)	162 (88.5%)	1411 (85.4%)
		Heterozygous	118 (5.4%)	73 (9%)	91 (11.1%)	91 (5.1%)	18 (9.8%)	156 (9.4%)
		Homozygous	14 (0.6%)	2 (0.2%)	4 (0.5%)	22 (1.2%)	0 (0%)	8 (0.5%)
	HFE H63D	Wild type	1645 (74.8%)	571 (70.8%)	587 (71.8%)	1366 (75.9%)	131 (71.6%)	1146 (69.4%)
		Heterozygous	383 (17.4%)	175 (21.7%)	177 (21.6%)	319 (17.7%)	44 (24%)	396 (24%)
		Homozygous	27 (1.2%)	16 (2%)	24 (2.9%)	28 (1.6%)	5 (2.7%)	33 (2%)
	TMPRSS6 A736V	Wild type	759 (34.5%)	289 (35.8%)	272 (33.3%)	621 (34.5%)	60 (32.8%)	553 (33.5%)
		Heterozygous	923 (42%)	347 (43%)	397 (48.5%)	778 (43.2%)	83 (45.4%)	748 (45.3%)
		Homozygous	373 (17%)	126 (15.6%)	119 (14.5%)	314 (17.4%)	37 (20.2%)	274 (16.6%)